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Nivolumab increases the proportion of lung cancer patients alive

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Results obtained during recent trials have revealed that the drug called Nivolumab (Opdivo), a PD-1 inhibitor, can improve survival of some lung cancer patients. To be more precise, researchers have found that the drug can reduce death risk of previously treated non-squamous NSCLC (non–small cell lung cancer) patients by 28% compared to what Docetaxel managed to do.

All the above mentioned facts are part of the updated findings obtained during the Phase III CheckMate-057 study. These findings were presented at this year’s European Cancer Congress in Vienna and were also published in The New England Journal of Medicine on September 27.

A follow up after 17.2 months showed that overall survival rate of patients with non-squamous NSCLC after being treated with Nivolumab was 39%. Docetaxel, on the other hand, could offer an overall survival rate of just 23%. Among patients treated with Nivolumab, the median overall survival was for 12.2 months; the number for Docetaxel was just 9.4 months.

As much as 19% patients in the Nivolumab group experienced one-year long progression-free survival. Just 8% in the Docetaxel group showed similar response. Objective response rates among patients treated with Nivolumab and Docetaxel, on the other hand, were respectively 19% and 12%.

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Patients in the Nivolumab group experienced AEs or adverse events much less frequently than those in the Docetaxel group. The rates of AEs of all grades were respectively 88% and 69% among patients treated with Docetaxel and Nivolumab. In the Nivolumab group, just 10% patients experienced AEs of grade 3 or 4 compared to 54% in the Docetaxel group.

Leora Horn of the Vanderbilt-Ingram Cancer Center, who happens to be the lead investigator of the study, said that these long term survival results for Nivolumab when used for treating advanced non-squamous NSCLC support the potentials of this drug as a treatment for lung cancer. She added that facts and figures thrown up by CheckMate-057 prove that Nivolumab is capable of offering a sustained survival benefit to patients suffering from this debilitating form of lung cancer.

According to Horn, the findings of the study are extremely encouraging for both patients diagnosed with the disease and oncologists.

A total of 582 patients with advanced non-squamous NSCLC participated in the study after platinum-based doublet chemotherapy failed to offer them any result.

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SOURCENew England Journal of Medicine
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An entrepreneur by birth, blogger by choice, and geek by heart. He founded Sprouts Media, a blogs/websites network company, currently owns over 10 popular web properties, to cater his passion of journalism and entrepreneurship. He is also known as an avid reader, technology enthusiast, explorer, and a broken lover. His passion for knowledge keeps him running all the time. A pure vegetarian, who believes in reincarnation & law of karma and follows the philosophy of “Live and let others Live” because all living beings have equal right on the resources of this planet. He loves to write about Technology and Social Issues on his blogs. He can be reached at nitin [at] sprouts.media.