The free radical theory of aging (FRTA) was first proposed by Denham Harman in 1950 and further extended the idea in 1970’s to indict mitochondrial production of reactive oxygen species. The free radical theory of aging further implies that antioxidants such as Vitamin C, Vitamin A, Alpha –tocopherol, selenium, can slow the process of aging. Most biologically-relevant free radicals are highly reactive, and its accumulation can cause damage over time. Antioxidants are reducing agents which preempt oxidative damage to biological structures.

The free radical theory of aging further implies that antioxidants such as Vitamin C, Vitamin A, Alpha –tocopherol, selenium, can slow the process of aging. Most biologically-relevant free radicals are highly reactive, and its accumulation can cause damage over time. Antioxidants are reducing agents which preempt oxidative damage to biological structures.

Most biologically-relevant free radicals are highly reactive, and its accumulation can cause damage over time. Antioxidants are reducing agents which preempt oxidative damage to biological structures.

Most biologically-relevant free radicals are highly reactive, and its accumulation can cause harm over time. Antioxidants are reducing agents which preempt oxidative damage to biological structures.

Did you know mangoes have numerous compounds that have antioxidant properties? Among these compounds are vitamin C, beta carotene, polyphenolic compounds such as gallic acid, gallotannic which are believed to have potent anti-carcinogenic and anti-inflammatory properties in –vitro and in –vivo studiesIn a human trial which has been published in Molecular Nutrition & Food Research. 11 volunteers between the ages of 21 and 38 years were given 400 gms mango pulp daily for ten days. The participants refrained from consuming supplements like berries, grapes and tea which could be a soured of gallic acid a week before starting the trials.

In a human trial which has been published in Molecular Nutrition & Food Research. 11 volunteers between the ages of 21 and 38 years were given 400 gms mango pulp daily for ten days. The participants refrained from consuming supplements like berries, grapes and tea which could be a soured of gallic acid a week before starting the trials

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Blood and urine samples of the volunteers were taken on the first and the last days of mango pulp consumption. Seven metabolites of Gallic acid were identified in the urine of the healthy volunteers. Two microbial metabolites were found to be significantly excreted more following ten days of mango consumption.
The high levels of Gallic acid metabolites in human urine indicate the absorption, metabolism, and excretion of Gallic acid derivatives and also confirm the bioavailability of these mangoes derived metabolites.

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